TGR5 in the Cholangiociliopathies.

  title={TGR5 in the Cholangiociliopathies.},
  author={Tatyana V. Masyuk and Anatoliy I Masyuk and Nicholas F. LaRusso},
  journal={Digestive diseases},
  volume={33 3},
A plasma membrane-bound G protein-coupled receptor, TGR5, that transmits bile acid signaling into a cellular response primarily via the cAMP pathway is expressed in human and rodent cholangiocytes and is localized to multiple, diverse subcellular compartments, including primary cilia. Ciliary-associated TGR5 plays an important role in cholangiocyte… CONTINUE READING