TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model

@inproceedings{Weissmller2016TGN1412IL,
  title={TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model},
  author={Sabrina Weissm{\"u}ller and Stefanie Kronhart and Dorothea Kreuz and Barbara S. Schnierle and Ulrich Kalinke and Joerg Kirberg and K Hanschmann and Zoe Waibler},
  booktitle={PloS one},
  year={2016}
}
Therapeutic monoclonal antibodies (mAbs) such as the superagonistic, CD28-specific antibody TGN1412, or OKT3, an anti-CD3 mAb, can cause severe adverse events including cytokine release syndrome. A predictive model for mAb-mediated adverse effects, for which no previous knowledge on severe adverse events to be expected or on molecular mechanisms underlying is prerequisite, is not available yet. We used a humanized mouse model of human peripheral blood mononuclear cell-reconstituted NOD-RAG1-/-A… CONTINUE READING
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TGN1412 Investigational Medicinal Product Dossier

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  • http://www.circare.org/
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