TGN1412: From Discovery to Disaster

@inproceedings{Attarwala2010TGN1412FD,
  title={TGN1412: From Discovery to Disaster},
  author={Husain Attarwala},
  booktitle={Journal of young pharmacists : JYP},
  year={2010}
}
After a drug is confirmed as safe and efficacious in preclinical studies, it is tested in healthy human volunteers for first in man trials. In 2006, a phase I clinical study was conducted for a CD28 superagonist antibody TGN1412 in six human volunteers. After very first infusion of a dose 500 times smaller than that found safe in animal studies, all six human volunteers faced life-threatening conditions involving multiorgan failure for which they were moved to intensive care unit. After this… CONTINUE READING