TGM2 Is a Novel Marker for Prognosis and Therapeutic Target in Colorectal Cancer

@article{Miyoshi2009TGM2IA,
  title={TGM2 Is a Novel Marker for Prognosis and Therapeutic Target in Colorectal Cancer},
  author={Norikatsu Miyoshi and Hideshi Ishii and Koshi Mimori and Fumiaki Tanaka and Toshiki Hitora and Mitsuyoshi Tei and Mitsugu Sekimoto and PhD FACS Yuichiro Doki and PhD FACS Masaki Mori},
  journal={Annals of Surgical Oncology},
  year={2009},
  volume={17},
  pages={967-972}
}
Transglutaminase 2 (TGM2) plays a role in cell growth and survival through the antiapoptosis signaling pathway. We analyzed TGM2 gene expression in 91 paired cases of colorectal cancer (CRC) and noncancerous regions and seven CRC cell lines to demonstrate the importance of TGM2 expression for the prediction of prognosis of CRC. TGM2 expression was higher in CRC tissue than in corresponding normal tissue by real-time reverse transcriptase–polymerase chain reaction (P = .015). Patients in the… CONTINUE READING