TGFbeta1 regulates the gating properties of intermediate-conductance KCa channels in developing parasympathetic neurons.

@article{Lhuillier1999TGFbeta1RT,
  title={TGFbeta1 regulates the gating properties of intermediate-conductance KCa channels in developing parasympathetic neurons.},
  author={Loic Lhuillier and Stuart E Dryer},
  journal={Journal of neurophysiology},
  year={1999},
  volume={82 3},
  pages={1627-31}
}
The developmental expression of Ca2+-activated K+ channels (KCa) in chick ciliary ganglion (CG) neurons is regulated by a target-derived avian isoform of TGFbeta1, which evokes a robust increase in the number of functional large-conductance (BK) KCa channels but which produces no change in their kinetics. However, CG neurons express multiple KCa channel subtypes. Here we show that TGFbeta1 regulates the gating properties of intermediate-conductance (IK) KCa channels in developing CG neurons. IK… CONTINUE READING

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