TGFbeta1 limits the expansion of the osteoprogenitor fraction in cultures of human bone marrow stromal cells.

@article{Walsh2003TGFbeta1LT,
  title={TGFbeta1 limits the expansion of the osteoprogenitor fraction in cultures of human bone marrow stromal cells.},
  author={Susan F. Walsh and Carolyn M. Jefferiss and Karina Stewart and Jon N. Beresford},
  journal={Cell and tissue research},
  year={2003},
  volume={311 2},
  pages={
          187-98
        }
}
Currently, there is considerable interest in the possibility of using cultured human bone marrow stromal cells (BMSCs) for skeletal tissue engineering. However, the factors that regulate their ex vivo expansion and promote their osteogenic maturation remain poorly defined. Using BMSCs obtained from a large cohort of adult donors, the effects of transforming growth factor (TGF)beta1 on these processes have been determined. BMSCs were found to express TGFbeta receptors (TbetaRs) I, II, III… CONTINUE READING

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