TGFbeta1-induced inflammation in premalignant epidermal squamous lesions requires IL-17.

Abstract

Overexpression of transforming growth factor-beta1 (TGFbeta1) in the normal epidermis can provoke an inflammatory response, but whether this occurs within a developing tumor is not clear. To test this, we used an inducible transgenic mouse to overexpress TGFbeta1 in premalignant squamous lesions. Within 48 hours of TGFbeta1 induction, there was an increase… (More)
DOI: 10.1038/jid.2010.92

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