TGFbeta directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes.

@article{Paglinawan2003TGFbetaDG,
  title={TGFbeta directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes.},
  author={Rey Paglinawan and Ursula Malipiero and Ralph Schlapbach and Karl Frei and Walter Reith and Adriano Fontana},
  journal={Glia},
  year={2003},
  volume={44 3},
  pages={219-31}
}
In experimental autoimmune encephalomyelitis, the acute phase of the disease is produced by T-helper lymphocyte type 1 (TH1), which produces mainly TNFalpha and IFNgamma. Recovery from the disease is mediated by T-helper lymphocyte types 2 and 3 (TH2/TH3), which, among other cytokines, produce transforming growth factor beta (TGFbeta). To address the influence of TGFbeta on TH1-induced gene expression, microarray technology was used on murine primary microglial cells stimulated with IFNgamma… CONTINUE READING

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