TGFbeta and PTHrP control chondrocyte proliferation by activating cyclin D1 expression.

  title={TGFbeta and PTHrP control chondrocyte proliferation by activating cyclin D1 expression.},
  author={Frank M. Beier and Zenobia Ali and Dereck C M Mok and Allison C. Taylor and Todd Leask and Chris Albanese and Richard G. Pestell and P A Luvalle},
  journal={Molecular biology of the cell},
  volume={12 12},
Exact coordination of growth plate chondrocyte proliferation is necessary for normal endochondral bone development and growth. Here we show that PTHrP and TGFbeta control chondrocyte cell cycle progression and proliferation by stimulating signaling pathways that activate transcription from the cyclin D1 promoter. The TGFbeta pathway activates the transcription factor ATF-2, whereas PTHrP uses the related transcription factor CREB, to stimulate cyclin D1 promoter activity via the CRE promoter… CONTINUE READING


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