TGFbeta activates mitogen- and stress-activated protein kinase-1 (MSK1) to attenuate cell death.

Abstract

Transforming growth factor-β (TGFβ) binding to its receptor leads to intracellular phosphorylation of Smad2 and Smad3, which oligomerize with Smad4. These complexes accumulate in the nucleus and induce gene transcription. Here we describe mitogen- and stress-activated kinase 1 (MSK1) as an antagonist of TGFβ-induced cell death. Induction of MSK1 activity by… (More)
DOI: 10.1074/jbc.M110.167379

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Statistics

0204020112012201320142015201620172018
Citations per Year

104 Citations

Semantic Scholar estimates that this publication has 104 citations based on the available data.

See our FAQ for additional information.

Slides referencing similar topics