TGFbeta activates mitogen- and stress-activated protein kinase-1 (MSK1) to attenuate cell death.


Transforming growth factor-β (TGFβ) binding to its receptor leads to intracellular phosphorylation of Smad2 and Smad3, which oligomerize with Smad4. These complexes accumulate in the nucleus and induce gene transcription. Here we describe mitogen- and stress-activated kinase 1 (MSK1) as an antagonist of TGFβ-induced cell death. Induction of MSK1 activity by… (More)
DOI: 10.1074/jbc.M110.167379


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