TGFalpha expression impairs Trastuzumab-induced HER2 downregulation.

@article{Valabrega2005TGFalphaEI,
  title={TGFalpha expression impairs Trastuzumab-induced HER2 downregulation.},
  author={Giorgio Valabrega and Filippo Montemurro and Ivana Sarotto and Annalisa Petrelli and Patrizia Rubini and Carlo Tacchetti and M. Et Al. Aglietta and Paolo Maria Comoglio and Silvia Giordano},
  journal={Oncogene},
  year={2005},
  volume={24 18},
  pages={
          3002-10
        }
}
The HER2 gene encodes a tyrosine kinase receptor overexpressed in 25-30% of human breast cancers. Clinical trials have shown the efficacy of the anti-HER2 monoclonal antibody Trastuzumab in metastatic breast cancer patients. Nevertheless, 70% of patients are unresponsive from start of treatment and nearly all become unresponsive during treatment. Possible mechanisms for these failures could depend on impairment of the machinery responsible for receptor downregulation. To test this hypothesis… CONTINUE READING

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