TGFBI gene mutations causing lattice and granular corneal dystrophies in Indian patients.

@article{Chakravarthi2005TGFBIGM,
  title={TGFBI gene mutations causing lattice and granular corneal dystrophies in Indian patients.},
  author={S V V Kalyana Chakravarthi and Chitra Kannabiran and Mittanamalli Shanmugam Sridhar and Geeta K Vemuganti},
  journal={Investigative ophthalmology & visual science},
  year={2005},
  volume={46 1},
  pages={121-5}
}
PURPOSE To identify mutations in the TGFBI gene in Indian patients with lattice corneal dystrophy (LCD) or granular corneal dystrophy (GCD) and to look for genotype-phenotype correlations. METHODS Thirty-seven unrelated patients were studied, 18 with LCD and 19 with GCD. The diagnosis of LCD or GCD was made on the basis of clinical and/or histopathological evaluation. Exons and flanking intron sequences of the TGFBI gene were amplified by PCR with specific primers. PCR products were screened… CONTINUE READING

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