TGFBI deficiency predisposes mice to spontaneous tumor development.

  title={TGFBI deficiency predisposes mice to spontaneous tumor development.},
  author={Yingjie Zhang and Gengyun Wen and Genze Shao and Cuidong Wang and Chyuansheng Lin and H. Y. Fang and Adayabalam S. Balajee and Govind Bhagat and Tom K. Hei and Yongliang Zhao},
  journal={Cancer research},
  volume={69 1},
Loss of TGFBI, a secreted protein induced by transforming growth factor-beta, has been implicated in cell proliferation, tumor progression, and angiogenesis by in vitro studies. However, in vivo antitumor functions of TGFBI as well as the underlying molecular mechanism are not well understood. To these aims, we have generated a mouse model with disruption of TGFBI genomic locus. Mice lacking TGFBI show a retarded growth and are prone to spontaneous tumors and 7,12-dimethylbenz(a)anthracene… CONTINUE READING
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