TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways.

@article{Martin2007TGFbeta1SH,
  title={TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways.},
  author={Mickey M. Martin and Jessica A. Buckenberger and Jinmai Jiang and Geraldine E. Malana and Daren L Knoell and David S. Feldman and Terry S. Elton},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={293 3},
  pages={L790-9}
}
Both angiotensin II (ANG II) and transforming growth factor-beta1 (TGF-beta1) are thought to be involved in mediating pulmonary fibrosis. Interactions between the renin-angiotensin system (RAS) and TGF-beta1 have been well documented, with most studies describing the effect of ANG II on TGF-beta1 expression. However, recent gene expression profiling experiments demonstrated that the angiotensin II type 1 receptor (AT(1)R) gene was a novel TGF-beta1 target in human adult lung fibroblasts. In… CONTINUE READING

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