TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function

@inproceedings{Rustenhoven2016TGFbeta1RH,
  title={TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function},
  author={Justin Rustenhoven and Miranda Aalderink and Emma L. Scotter and Robyn L. Oldfield and Peter S Bergin and Edward W. Mee and E. Scott Graham and Richard L. M. Faull and Maurice A Curtis and Thomas I-H. Park and Mike Dragunow},
  booktitle={Journal of Neuroinflammation},
  year={2016}
}
  • Justin Rustenhoven, Miranda Aalderink, +8 authors Mike Dragunow
  • Published in Journal of Neuroinflammation 2016
  • Biology, Medicine
  • BackgroundTransforming growth factor beta 1 (TGFβ1) is strongly induced following brain injury and polarises microglia to an anti-inflammatory phenotype. Augmentation of TGFβ1 responses may therefore be beneficial in preventing inflammation in neurological disorders including stroke and neurodegenerative diseases. However, several other cell types display immunogenic potential and identifying the effect of TGFβ1 on these cells is required to more fully understand its effects on brain… CONTINUE READING

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