TGF-beta1 regulates TGF-beta1 and FGF-2 mRNA expression during fibroblast wound healing.

@article{Song2002TGFbeta1RT,
  title={TGF-beta1 regulates TGF-beta1 and FGF-2 mRNA expression during fibroblast wound healing.},
  author={Q. H. Song and V E Klepeis and Matthew A. Nugent and Vickery E Trinkaus-Randall},
  journal={Molecular pathology : MP},
  year={2002},
  volume={55 3},
  pages={164-76}
}
AIMS To evaluate the expression of transforming growth factor beta1 (TGF-beta1) and fibroblast growth factor 2 (FGF-2) mRNA in stromal cells in response to injury in the presence of either TGF-beta1 or FGF-2. It has been shown previously that heparan sulfate proteoglycans and FGF-2 are present transiently during wound repair in vivo and that an increase in TGF-beta1 mRNA is detected rapidly after injury. METHODS Primary corneal fibroblasts were cultured to confluency, serum starved, and… CONTINUE READING

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