TGF-beta1 promotes migration and invasion of salivary adenoid cystic carcinoma.

@article{Dong2011TGFbeta1PM,
  title={TGF-beta1 promotes migration and invasion of salivary adenoid cystic carcinoma.},
  author={Ling Dong and Yun Xia Wang and Shao Lin Li and Guo Ying Yu and Y H Gan and Donghai Li and Chen Yu Wang},
  journal={Journal of dental research},
  year={2011},
  volume={90 6},
  pages={804-9}
}
Salivary adenoid cystic carcinoma (SACC) is one of the most common subtypes of salivary gland carcinomas and frequently metastasizes to distant organs. However, little is known about the molecular mechanisms that promote SACC metastasis. In this study, we report that transforming growth factor (TGF)-β1 was highly expressed in the highly metastatic SACC-LM cell line as compared with its parental low-metastatic SACC-83 cell line. Exogenous addition of TGF-β1 induced Smad2 phosphorylation and… CONTINUE READING

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