TGF-beta1-mediated alterations of renal proximal tubular epithelial cell phenotype.

  title={TGF-beta1-mediated alterations of renal proximal tubular epithelial cell phenotype.},
  author={Ya Chung Tian and Donald J Fraser and Liliana Attisano and Aled O Phillips},
  journal={American journal of physiology. Renal physiology},
  volume={285 1},
The aim of this study was to characterize the mechanism of transforming growth factor (TGF)-beta1-mediated alteration of renal proximal tubular cell phenotype. TGF-beta1 altered cell phenotype, with cells appearing elongated and spindle shaped. This was associated with loss of cell-cell contact and rearrangement of the actin cytoskeleton, increased formation of stress fibers, and focal adhesions. Addition of the tyrosine phosphatase inhibitor sodium orthovanadate also led to rapid but transient… CONTINUE READING
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