TGF-beta1 and C-erb-B2 neu oncoprotein in Egyptian HCV related chronic liver disease and hepatocellular carcinoma patients.

@article{Bassuoni2008TGFbeta1AC,
  title={TGF-beta1 and C-erb-B2 neu oncoprotein in Egyptian HCV related chronic liver disease and hepatocellular carcinoma patients.},
  author={Maha A El Bassuoni and Randa M Talaat and Amany Ahmad Ibrahim and Olfat T Shaker},
  journal={The Egyptian journal of immunology},
  year={2008},
  volume={15 1},
  pages={39-50}
}
Transforming growth factor beta (TGF-beta), a pro-fibrogenic cytokine, has several polymorphism in humans with difference in activity levels. Hepato-carcinogenesis involves alterations in the action of protooncogenes such as the; neu (C-erb-B2) oncogene. Overexpression of the neu-oncogene has been implicated in experimental cellular transformation and tumorigenesis in a wide range of human cancer. We examined TGF-beta1 and C-erb-B2 mRNA expression and their protein levels in hepatitis C virus… CONTINUE READING