TGF-beta1: immunosuppressant and viability factor for T lymphocytes.

  title={TGF-beta1: immunosuppressant and viability factor for T lymphocytes.},
  author={Adelheid Cerwenka and Susan L Swain},
  journal={Microbes and infection},
  volume={1 15},
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine with multiple roles in the immune system. To date, it has been difficult to develop a comprehensive picture of the effect of TGF-beta on T lymphocytes, because TGF-beta not only acts directly on T lymphocytes, but also acts indirectly by regulating the function of antigen-presenting cells. In early studies, it was mostly the inhibitory function of TGF-beta that was demonstrated; recently, however TGF-beta was recognized as… CONTINUE READING

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