TGF-beta1/SMAD signaling induces astrocyte fate commitment in vitro: implications for radial glia development.

@article{Stipursky2007TGFbeta1SMADSI,
  title={TGF-beta1/SMAD signaling induces astrocyte fate commitment in vitro: implications for radial glia development.},
  author={Joice Stipursky and Fl{\'a}via Carvalho Alc{\^a}ntara Gomes},
  journal={Glia},
  year={2007},
  volume={55 10},
  pages={
          1023-33
        }
}
Radial glial (RG) cells are specialized type of cell, which functions as neuronal precursors and scaffolding guides to migrating neurons during cerebral cortex development. After neurogenesis and migration are completed, most of RG cells transform into astrocytes. Mechanism and molecules involved in this process are not completely elucidated. We previously demonstrated that neurons activate the promoter of the astrocyte maturation marker GFAP in astrocytes by secretion of transforming growth… CONTINUE READING

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