TGF-beta up-regulates serum response factor in activated hepatic stellate cells.

@article{Herrmann2007TGFbetaUS,
  title={TGF-beta up-regulates serum response factor in activated hepatic stellate cells.},
  author={Jens Herrmann and Ute Haas and Axel M. Gressner and Ralf Weiskirchen},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1772 11-12},
  pages={1250-7}
}
In differentiated smooth muscle cells (SMC) the regulation of SMC marker genes (e.g. alpha-smooth muscle actin) is mainly conducted by the serum response factor (SRF) and accessory co-factors like myocardin. A number of SMC markers are also expressed in activated hepatic stellate cells which are the main cellular effectors in liver fibrogenesis. In the present study we found that during cellular activation and transdifferentiation the SRF transcription factor is up-regulated by transforming… CONTINUE READING