TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300.

@article{Janknecht1998TGFbetastimulatedCO,
  title={TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300.},
  author={Ralf Janknecht and Nicholas J. Wells and Tony Hunter},
  journal={Genes & development},
  year={1998},
  volume={12 14},
  pages={2114-9}
}
TGF-beta and activin induce the phosphorylation and activation of Smad2 and Smad3, but how these proteins stimulate gene transcription is poorly understood. We report that TGF-beta receptor phosphorylation of Smad3 promotes its interaction with the paralogous coactivators CBP and p300, whereas CBP/p300 binding to nonphosphorylated Smad3 or its… CONTINUE READING