TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons

@inproceedings{Kandasamy2014TGFbetaSI,
  title={TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons},
  author={Mahesh Kandasamy and Bernadette Lehner and Sabrina Kraus and Paul Ramm Sander and Julia Marschallinger and Francisco J Rivera and Dietrich Tr{\"u}mbach and Uwe Ueberham and Herbert A. Reitsamer and Olaf Strauss and U. Bogdahn and Sebastien Couillard-Despres and Ludwig Aigner},
  booktitle={Journal of cellular and molecular medicine},
  year={2014}
}
Members of the transforming growth factor (TGF)-β family govern a wide range of mechanisms in brain development and in the adult, in particular neuronal/glial differentiation and survival, but also cell cycle regulation and neural stem cell maintenance. This clearly created some discrepancies in the field with some studies favouring neuronal differentiation/survival of progenitors and others favouring cell cycle exit and neural stem cell quiescence/maintenance. Here, we provide a unifying… CONTINUE READING

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