TGF beta signalling and its role in tumour pathogenesis.

  title={TGF beta signalling and its role in tumour pathogenesis.},
  author={Bozena Kaminska and Aleksandra Wesolowska and Malgorzata Danilkiewicz},
  journal={Acta biochimica Polonica},
  volume={52 2},
Transforming growth factor beta (TGF-beta) is a multifunctional cytokine involved in the regulation of cell proliferation, differentiation and survival/or apoptosis of many cells. Knock-out experiments in mice for the three isoforms of TGF-beta have demonstrated their importance in regulating inflammation and tissue repair. TGF-beta is implicated in the pathogenesis of human diseases, including tissue fibrosis and carcinogenesis. TGF-beta receptors act through multiple intracellular pathways… CONTINUE READING


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