TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses.

  title={TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses.},
  author={Li J. Yu and Mindy C H{\'e}bert and Ying E Zhang},
  journal={The EMBO journal},
  volume={21 14},
Through the action of its membrane-bound type I receptors, transforming growth factor-beta (TGF-beta) elicits a wide range of cellular responses that regulate cell proliferation, differentiation and apoptosis. Many of the signaling responses induced by TGF-beta are mediated by Smad proteins, but certain evidence has suggested that TGF-beta can also signal independently of Smads. We found in mouse mammary epithelial (NMuMG) cells, which respond to TGF-beta treatment in multiple ways, that TGF… CONTINUE READING
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