TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase.

  title={TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase.},
  author={Chuan-Wei Jang and Chun-Han Chen and Chun-Chieh Chen and Jia-Yun Chen and Yi-Hsien Su and R H Chen},
  journal={Nature cell biology},
  volume={4 1},
Transforming growth factor-beta (TGF-beta) and TGF-beta-related factors induce apoptosis in a variety of tissues; however, the mechanism underlying this induction is largely unknown. Here, we demonstrate that TGF-beta induces the expression of the death-associated protein kinase (DAP-kinase) as an immediate early response in cells that undergo apoptosis in response to TGF-beta. DAP-kinase is a positive mediator of apoptosis induced by certain cytokines and oncogenes. We show that the DAP-kinase… CONTINUE READING


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