TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing.

@article{Schiller2004TGFbetainducedSS,
  title={TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing.},
  author={Meinhard Schiller and Delphine Javelaud and Alain Mauviel},
  journal={Journal of dermatological science},
  year={2004},
  volume={35 2},
  pages={
          83-92
        }
}
Members of the transforming growth factor-beta (TGF-beta) superfamily are pleiotropic cytokines that have the ability to regulate numerous cell functions, including proliferation, differentiation, apoptosis, epithelial-mesenchymal transition, and production of extracellular matrix, allowing them to play an important role during embryonic development and for maintenance of tissue homeostasis. Three TGF-beta isoforms have been identified in mammals. They propagate their signal via a signal… CONTINUE READING
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