TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma.

@article{Peuelas2009TGFbetaIG,
  title={TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma.},
  author={Silvia Pe{\~n}uelas and Judit Anido and Rosa M Prieto-S{\'a}nchez and Gerard Folch and Ignasi Barba and Isabel Cuartas and David Garcia-Dorado and Maria A Poca and Juan Sahuquillo and Jos{\'e} Baselga and Juan Ram{\'o}n Quint{\'a}s Seoane},
  journal={Cancer cell},
  year={2009},
  volume={15 4},
  pages={
          315-27
        }
}
Glioma-initiating cells (GICs) are responsible for the initiation and recurrence of gliomas. Here, we identify a molecular mechanism that regulates the self-renewal capacity of patient-derived GICs. We show that TGF-beta and LIF induce the self-renewal capacity and prevent the differentiation of GICs. TGF-beta induces the self-renewal capacity of GICs, but not of normal human neuroprogenitors, through the Smad-dependent induction of LIF and the subsequent activation of the JAK-STAT pathway. The… CONTINUE READING

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