TGF-beta in allogeneic stem cell transplantation: friend or foe?

  title={TGF-beta in allogeneic stem cell transplantation: friend or foe?},
  author={Tatjana Banovic and Kelli P A MacDonald and Edward S Morris and Vanessa Rowe and Rachel D Kuns and Alistair L. J. Don and Jane Kelly and S. Ledbetter and Andrew D Clouston and Geoffrey R Hill},
  volume={106 6},
Donor treatment with granulocyte-colony-stimulating factor (G-CSF) attenuates the ability of donor T cells to induce acute graft-versus-host disease (aGVHD) but increases the severity of chronic GVHD (cGVHD). We investigated the role of the regulatory cytokine transforming growth factor beta (TGF-beta) in this paradox in well-established murine models of aGVHD and cGVHD wherein recipients undergo transplantation with splenocytes from donors treated with G-CSF. Neutralization of TGF-beta after… CONTINUE READING


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Cytokines in Graft-versus-Host Disease.

Journal of immunology • 2015
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