TGF-beta cytokines increase senescence-associated beta-galactosidase activity in human prostate basal cells by supporting differentiation processes, but not cellular senescence.

@article{Untergasser2003TGFbetaCI,
  title={TGF-beta cytokines increase senescence-associated beta-galactosidase activity in human prostate basal cells by supporting differentiation processes, but not cellular senescence.},
  author={Gerold Untergasser and Roland Gander and Holger F Rumpold and Eileen L. Heinrich and Eugen G. Plas and Peter Berger},
  journal={Experimental gerontology},
  year={2003},
  volume={38 10},
  pages={1179-88}
}
The family of transforming growth factors betas (TGF-betas) comprises molecules involved in growth inhibition, stress-induced premature senescence, epithelial mesenchymal transition and differentiation processes. The aim of this study was to clarify the effect of long term exposure of human prostate basal cells to TGF-betas, which are found in high concentrations in prostatic fluid and areas of benign prostatic hyperplasia (BPH). Basal cell cultures established from prostate explants (n=3) were… CONTINUE READING

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