TGF-beta and bFGF affect the differentiation of proliferating porcine fibroblasts into myofibroblasts in vitro.

@article{Khouw1999TGFbetaAB,
  title={TGF-beta and bFGF affect the differentiation of proliferating porcine fibroblasts into myofibroblasts in vitro.},
  author={Ilse MSL Khouw and Pauline B van Wachem and Jos{\'e}e A. Plantinga and Zeljko Vujaskovi{\'c} and M J Wissink and Lou F. M. H. de Leij and Marja J A van Luyn},
  journal={Biomaterials},
  year={1999},
  volume={20 19},
  pages={1815-22}
}
Fibroblasts and myofibroblasts are involved in the foreign body reaction to biomaterials, especially in capsule formation. However, contraction or detachment of the capsule can lead to complications. Biocompatibility of biomaterials may be improved by the application of proteins regulating the differentiation or activation of (myo)fibroblasts. Myofibroblasts, differentiating from fibroblasts can be identified by the expression of alpha-smooth muscle actin (alpha-SM actin). We investigated the… CONTINUE READING

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