TGF-beta and PDGF act synergistically in affecting the growth of human osteoblast-enriched cultures.

@article{Kells1995TGFbetaAP,
  title={TGF-beta and PDGF act synergistically in affecting the growth of human osteoblast-enriched cultures.},
  author={Amy F. Kells and Stephen R. Coats and Herbert S. Schwartz and Richard L. Hoover},
  journal={Connective tissue research},
  year={1995},
  volume={31 2},
  pages={117-24}
}
Transforming growth factor beta (TGF-beta) is a polypeptide found in high concentrations in bone and is produced by and acts on primary adult human derived osteoblast-enriched cultures (PHO cells). Receptors for TGF-beta are present on PHO cells and TGF-beta is mitogenic for these cells. Results of these studies in conjunction with those of others suggest that TGF-beta may have an important therapeutic role in orthopaedic surgery; however, with respect to its mitogenic actions, further studies… CONTINUE READING