TGF-beta and 'adaptive' Foxp3(+) regulatory T cells.

  title={TGF-beta and 'adaptive' Foxp3(+) regulatory T cells.},
  author={Wanjun Chen and Joanne E Konkel},
  journal={Journal of molecular cell biology},
  volume={2 1},
In naïve T cells transforming growth factor-beta (TGF-beta) induces Foxp3, a transcription factor essential for programming and developing T regulatory cells (Treg cells). This finding reveals a physiological factor which can turn on the Foxp3 gene and establishes an experimental approach to induce antigen-specific Treg cells as a potential therapy for… CONTINUE READING

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