TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases.

  title={TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases.},
  author={Khalid S. Mohammad and Delphine Javelaud and Pierrick G. J. Fournier and Maria Niewolna and Christopher R McKenna and Xiang Hong Peng and Vu Duong and Lauren K. Sauzer Dunn and Alain Mauviel and Theresa A. Guise},
  journal={Cancer research},
  volume={71 1},
Melanoma often metastasizes to bone where it is exposed to high concentrations of TGF-β. Constitutive Smad signaling occurs in human melanoma. Because TGF-β promotes metastases to bone by several types of solid tumors including breast cancer, we hypothesized that pharmacologic blockade of the TGF-β signaling pathway may interfere with the capacity of melanoma cells to metastasize to bone. In this study, we tested the effect of a small molecule inhibitor of TGF-β receptor I kinase (TβRI), SD-208… CONTINUE READING
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