TGF-beta 2 decreases migration of lymphocytes in vitro and homing of cells into the central nervous system in vivo.

@article{Fabry1995TGFbeta2D,
  title={TGF-beta 2 decreases migration of lymphocytes in vitro and homing of cells into the central nervous system in vivo.},
  author={Zsuzsa Fabry and David J. Topham and Dominic B. Fee and Judith A. Herlein and J A Carlino and Michael Noel Hart and Subramaniam Sriram},
  journal={Journal of immunology},
  year={1995},
  volume={155 1},
  pages={325-32}
}
Migration of leukocytes through an in vitro, cell culture model of the blood-brain barrier (BBB) composed of murine brain microvessel endothelial (En) cells and astrocytes, and in vivo in experimental allergic encephalomyelitis (EAE), was investigated. We have recently shown that the adhesiveness of cultured murine brain microvascular endothelial cells for lymphocytes can be increased significantly by pretreatment with IL-1 beta, TNF-alpha, IFN-gamma, and LPS. In the present study, we… CONTINUE READING