TGF-beta 1 codon 10 polymorphism is associated with cerebral SVD.

  title={TGF-beta 1 codon 10 polymorphism is associated with cerebral SVD.},
  author={Hong-miao Tao and Guo-zhong Chen and Xiao-dong Lu and Xiao-Gang Hu and Gan-ping Chen and Bei Shao},
  journal={The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques},
  volume={38 6},
BACKGROUND To clarify the role of inflammation in the pathogenesis of cerebral small vessel disease (SVD), we investigated whether the gene encoding transforming growth factor-beta 1(TGF-beta 1) is a risk factor for cerebral SVD as a whole, and for two different SVD subtypes. METHODS TGF-beta 1 codon10 (T+29C) genotype was determined in 441 Chinese patients (313 male and 128 female) with cerebral SVD and 450 control subjects (326 male and 124 female). Cerebral SVD patients were… CONTINUE READING