TGF beta-1 and TNF alpha expression in the epidermis of patients with epidermodysplasia verruciformis.

@article{Majewski1991TGFBA,
  title={TGF beta-1 and TNF alpha expression in the epidermis of patients with epidermodysplasia verruciformis.},
  author={Sĺawomir Majewski and Nicolas Hunzelmann and Roswitha Nischt and Beate Eckes and Lidia Rudnicka and G{\'e}rard Orth and Thomas Krieg and Stephania Jablonska},
  journal={The Journal of investigative dermatology},
  year={1991},
  volume={97 5},
  pages={862-7}
}
In epidermodysplasia verruciformis (EV), the infection with specific human papillomaviruses (HPV) might be under control of the local immunosurveillance mechanisms related to cytokines produced by epidermal cells. We have investigated by in situ hybridization the expression of mRNA coding for TGF beta-1 and TNF alpha in the skin of patients with EV (n = 4) as compared to the skin lesions of patients with other premalignant (actinic keratosis; n = 5) or malignant (squamous cell carcinoma; n = 4… CONTINUE READING
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