TGF-beta 1 and IL-10 modulate IL-1 beta-induced membrane and soluble ICAM-1 in human myoblasts.

@article{Marino2003TGFbeta1A,
  title={TGF-beta 1 and IL-10 modulate IL-1 beta-induced membrane and soluble ICAM-1 in human myoblasts.},
  author={Mariapaola Marino and Flavia Scuderi and Francesca Mannella and Emanuela Bartoccioni},
  journal={Journal of neuroimmunology},
  year={2003},
  volume={134 1-2},
  pages={
          151-7
        }
}
We have previously shown that interleukin (IL)-1 beta and other inflammatory cytokines are able to induce the expression of membrane and soluble intercellular adhesion molecule (ICAM)-1 on human myoblasts. In this paper we found that IL-10 and transforming growth factor (TGF)-beta 1 are able to prevent IL-1 beta-induced membrane and soluble ICAM-1 protein expression on human myoblasts, with different time courses. The effect of both cytokines is associated to a reduction in ICAM-1 mRNA. Our… CONTINUE READING

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