Corpus ID: 38595970

TGF-beta/Smad signaling in the injured liver.

@article{Breitkopf2006TGFbetaSmadSI,
  title={TGF-beta/Smad signaling in the injured liver.},
  author={K. Breitkopf and P. Godoy and L. Ciuclan and M. Singer and S. Dooley},
  journal={Zeitschrift fur Gastroenterologie},
  year={2006},
  volume={44 1},
  pages={
          57-66
        }
}
TGF-beta, acting both directly and indirectly, represents a central mediator of fibrogenic remodeling processes in the liver. Besides hepatic stellate cells (HSCs), which are induced by TGF-beta to transdifferentiate to myofibroblasts and to produce extracellular matrix, hepatocytes are also strongly responsive for this cytokine, which induces apoptosis during fibrogenesis and provides growth control in regeneration processes. Based on this, TGF-beta-mediated hepatic responses to injury are the… Expand
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