TGF-b signaling of human T cells is modulated by the ancillary TGF-b receptor endoglin

Abstract

Transforming growth factor beta (TGF-b) inhibits T cell activation and alters differentiation of naive T cells into effector cells. Although four main cell-surface proteins can interact with TGF-b, only the signaling receptors type I (TGF-bR type I) and type II (TGF-bR type II) have so far been described on T cells. The aim of the present study was to… (More)

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