TGF b-like Signaling and Spicule Development n Caenorhabditis elegans

@inproceedings{Baird1999TGFBS,
  title={TGF b-like Signaling and Spicule Development n Caenorhabditis elegans},
  author={Scott Everet Baird and Sharon A. Ellazar},
  year={1999}
}
A TGFb-like signal is required for spicule development in Caenorhabditis elegans males. This signal appears to originate in the male-specific musculature and is required for the migrations of cells within the proctodeum. The migrations of these cells form cellular molds, the spicule traces, in which the cuticle of the spicules is secreted. Mutations in daf-4, sma-2, sma-3, and sma-4, which disrupt TGFb-like signaling, result in aberrant migrations and morphologically abnormal spicules. af-4… CONTINUE READING