TGF-b Does Not Inhibit IL-12- and IL-2-Induced Activation of Janus Kinases and STATs

Abstract

The immune system is an important target for the cytokine TGF-b1, whose actions on lymphocytes are largely inhibitory. TGF-b has been reported to inhibit IL-12and IL-2-induced cell proliferation and IFN-g production by T cells and NK cells; however, the mechanisms of inhibition have not been clearly defined. It has been suggested by some studies that TGF-b… (More)

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