TGF-β2 induces transdifferentiation and fibrosis in human lens epithelial cells via regulating gremlin and CTGF.

@article{Ma2014TGF2IT,
  title={TGF-β2 induces transdifferentiation and fibrosis in human lens epithelial cells via regulating gremlin and CTGF.},
  author={Bo Ma and Qianyan Kang and Li Qin and Lijun Cui and Cheng Pei},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={447 4},
  pages={689-95}
}
Transforming growth factor (TGF)-β2, gremlin and connective tissue growth factor (CTGF) are known to play important roles in the induction of epithelial mesenchymal transition (EMT) and extracellular matrix (ECM) synthesis. However, the complex functional relationship among gremlin, CTGF and TGF-β2 in the induction of EMT and ECM synthesis in human lens epithelial cells (HLECs) has not been reported. In this study, we found that TGF-β2, CTGF and gremlin can individually induce the expression of… CONTINUE READING
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