TGF-β1 regulation of multidrug resistance P-glycoprotein in the developing male blood-brain barrier.

@article{Baello2014TGF1RO,
  title={TGF-β1 regulation of multidrug resistance P-glycoprotein in the developing male blood-brain barrier.},
  author={Stephanie Baello and Majid I. Iqbal and Enrrico Bloise and Mohsen Javam and William R Gibb and Stephen G. Matthews},
  journal={Endocrinology},
  year={2014},
  volume={155 2},
  pages={475-84}
}
P-glycoprotein (P-gp), an efflux transporter encoded by the abcb1 gene, protects the developing fetal brain. Levels of P-gp in endothelial cells of the blood-brain barrier (BBB) increase dramatically during the period of peak brain growth. This is coincident with increased release of TGF-β1 by astrocytes and neurons. Although TGF-β1 has been shown to modulate P-gp activity in a number of cell types, little is known about how TGF-β1 regulates brain protection. In the present study, we… CONTINUE READING
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