TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice

@article{WyssCoray2001TGF1PM,
  title={TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice},
  author={Tony Wyss-Coray and Carol Lin and Fengrong Yan and G. Yu and Michelle Rohde and LISA C. McCONLOGUE and Eliezer Masliah and Lennart Mucke},
  journal={Nature Medicine},
  year={2001},
  volume={7},
  pages={612-618}
}
Abnormal accumulation of the amyloid-β peptide (Aβ) in the brain appears crucial to pathogenesis in all forms of Alzheimer disease (AD), but the underlying mechanisms in the sporadic forms of AD remain unknown. Transforming growth factor β1 (TGF-β1), a key regulator of the brain's responses to injury and inflammation, has been implicated in Aβ deposition in vivo. Here we demonstrate that a modest increase in astroglial TGF-β1 production in aged transgenic mice expressing the human β-amyloid… CONTINUE READING
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Expression of human apolipoprotein E reduces amyloid - β deposition in a mouse model of Alzheimer ’ s disease

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