TGF-β1 promotes linear invadosome formation in hepatocellular carcinoma cells, through DDR1 up-regulation and collagen I cross-linking.

@article{Ezzoukhry2016TGF1PL,
  title={TGF-β1 promotes linear invadosome formation in hepatocellular carcinoma cells, through DDR1 up-regulation and collagen I cross-linking.},
  author={Zakaria Ezzoukhry and Elodie Henriet and L{\'e}o Piquet and Kevin Boy{\'e} and Paulette Bioulac-Sage and Charles Balabaud and Gabrielle Couchy and Jessica Zucman-Rossi and Violaine Moreau and Fr{\'e}d{\'e}ric Saltel},
  journal={European journal of cell biology},
  year={2016},
  volume={95 11},
  pages={503-512}
}
Transforming growth factor-β1 (TGF-β1) is an important player in chronic liver diseases inducing fibrogenesis and hepatocellular carcinoma (HCC) development. TGF-β1 promotes pleiotropic modifications at the cellular and matrix microenvironment levels. TGF-β1 was described to enhance production of type I collagen and its associated cross-linking enzyme, the… CONTINUE READING