TGF-β1 induces HMGA1 expression in human breast cancer cells: Implications of the involvement of HMGA1 in TGF-β signaling

@inproceedings{Zu2015TGF1IH,
  title={TGF-β1 induces HMGA1 expression in human breast cancer cells: Implications of the involvement of HMGA1 in TGF-β signaling},
  author={Xuyu Zu and Jing Zhong and Jingjing Tan and L Tan and Dong Yang and Qinghai Zhang and Wenjun Ding and Wen Bin Liu and Gebo Wen and Jianghua Liu and Renxian Cao and Yuyang Jiang},
  booktitle={International journal of molecular medicine},
  year={2015}
}
Transforming growth factor-β1 (TGF-β1) signaling and high mobility group A (HMGA1) are known to play essential roles in the progression of breast cancer by inducing epithelial-mesenchymal transition. However, the correlation between TGF-β1 and HMGA1 in breast cancer cell is not yet well understood. In this study, we determined the effects of TGF-β1 on HMGA1 expression in breast cancer cells and examined the role of HMGA1 in breast cancer progression. Our results demonstrated that TGF-β1 induced… CONTINUE READING

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