TGF-β1 enhances contractility in engineered skeletal muscle.

@article{Weist2013TGF1EC,
  title={TGF-β1 enhances contractility in engineered skeletal muscle.},
  author={Michael R. Weist and Michael S Wellington and Jacob E Bermudez and Tatiana Y Kostrominova and Christopher L Mendias and Ellen M. Arruda and Lisa M Larkin},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2013},
  volume={7 7},
  pages={
          562-71
        }
}
Scaffoldless engineered 3D skeletal muscle tissue created from satellite cells offers the potential to replace muscle tissue that is lost due to severe trauma or disease. Transforming growth factor-beta 1 (TGF-β1) plays a vital role in mediating migration and differentiation of satellite cells during the early stages of muscle development. Additionally, TGF-β1 promotes collagen type I synthesis in the extracellular matrix (ECM) of skeletal muscle, which provides a passive elastic substrate to… CONTINUE READING
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