TGF-β1 and hypoxia-dependent expression of MKP-1 leads tumor resistance to death receptor-mediated cell death

@inproceedings{Park2013TGF1AH,
  title={TGF-β1 and hypoxia-dependent expression of MKP-1 leads tumor resistance to death receptor-mediated cell death},
  author={Jong Kuk Park and J H Lee and Wonseok Kang and Stewart T. Chang and E-C Shin and Chul Hee Choi},
  booktitle={Cell Death and Disease},
  year={2013}
}
Sporadic occurrence of transformed tumor cells is under the surveillance of the host immune system and such cells are effectively eliminated by immune-mediated cell death. During tumor progression, the antitumor effects of the tumor microenvironment are suppressed by diverse immunosuppressive mechanisms. In this research, we suggest novel immune evasion strategy of tumor cells through a transforming growth factor (TGF)-β1- and hypoxia-dependent mechanism. Experimental results showed that TGF-β1… CONTINUE READING

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